Pumps are more sophisticated devices. They have a large chamber that is filled with a drug, usually 1 to 1½ ounces (30 to 50 mL). The pump has a mechanism, driven by the body's heat, that allows the drug to be delivered constantly through a small catheter inserted into a vein or artery without the need for a stay in the hospital. It is sometimes possible to target a specific organ such as the liver and deliver large amounts of chemo- therapy drugs directly to it through an artery. To support radiation therapy , an operation can be performed to implant catheters that are subsequently loaded with a radioemitter.